SrasV1, Main, Exploration, bibRecord, 002947

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

Identifieur interne : 002947 ( Main/Exploration ); précédent : 002946; suivant : 002948

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

Auteurs : Barry R. O'Keefe [États-Unis] ; Barbara Giomarelli [États-Unis] ; Dale L. Barnard [États-Unis] ; Shilpa R. Shenoy [États-Unis] ; Paul K. S. Chan [Hong Kong] ; James B. Mcmahon [États-Unis] ; Kenneth E. Palmer [États-Unis] ; Brian W. Barnett [États-Unis] ; David K. Meyerholz [États-Unis] ; Christine L. Wohlford-Lenane [États-Unis] ; Paul B. Jr Mccray [États-Unis]

Source :

Journal of virology [ 0022-538X ] ; 2010.

RBID : Pascal:10-0140088

Descripteurs français

Pascal (Inist)
- Virus syndrome respiratoire aigu sévère, Activité biologique, In vitro, Efficacité, Antiviral, Protéine, Mécanisme action, Griffithsine.

English descriptors

KwdEn :
- Antiviral, Biological activity, Efficiency, Griffithsin, In vitro, Mechanism of action, Protein, Severe acute respiratory syndrome virus.

Abstract

Viruses of the family Coronaviridae have recently emerged through zoonotic transmission to become serious human pathogens. The pathogenic agent responsible for severe acute respiratory syndrome (SARS), the SARS coronavirus (SARS-CoV), is a member of this large family of positive-strand RNA viruses that cause a spectrum of disease in humans, other mammals, and birds. Since the publicized outbreaks of SARS in China and Canada in 2002-2003, significant efforts successfully identified the causative agent, host cell receptor(s), and many of the pathogenic mechanisms underlying SARS. With this greater understanding of SARS-CoV biology, many researchers have sought to identify agents for the treatment of SARS. Here we report the utility of the potent antiviral protein griffithsin (GRFT) in the prevention of SARS-CoV infection both in vitro and in vivo. We also show that GRFT specifically binds to the SARS-CoV spike glycoprotein and inhibits viral entry. In addition, we report the activity of GRFT against a variety of additional coronaviruses that infect humans, other mammals, and birds. Finally, we show that GRFT treatment has a positive effect on morbidity and mortality in a lethal infection model using a mouse-adapted SARS-CoV and also specifically inhibits deleterious aspects of the host immunological response to SARS infection in mammals.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral</term>
<term>Biological activity</term>
<term>Efficiency</term>
<term>Griffithsin</term>
<term>In vitro</term>
<term>Mechanism of action</term>
<term>Protein</term>
<term>Severe acute respiratory syndrome virus</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Virus syndrome respiratoire aigu sévère</term>
<term>Activité biologique</term>
<term>In vitro</term>
<term>Efficacité</term>
<term>Antiviral</term>
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<front><div type="abstract" xml:lang="en">Viruses of the family Coronaviridae have recently emerged through zoonotic transmission to become serious human pathogens. The pathogenic agent responsible for severe acute respiratory syndrome (SARS), the SARS coronavirus (SARS-CoV), is a member of this large family of positive-strand RNA viruses that cause a spectrum of disease in humans, other mammals, and birds. Since the publicized outbreaks of SARS in China and Canada in 2002-2003, significant efforts successfully identified the causative agent, host cell receptor(s), and many of the pathogenic mechanisms underlying SARS. With this greater understanding of SARS-CoV biology, many researchers have sought to identify agents for the treatment of SARS. Here we report the utility of the potent antiviral protein griffithsin (GRFT) in the prevention of SARS-CoV infection both in vitro and in vivo. We also show that GRFT specifically binds to the SARS-CoV spike glycoprotein and inhibits viral entry. In addition, we report the activity of GRFT against a variety of additional coronaviruses that infect humans, other mammals, and birds. Finally, we show that GRFT treatment has a positive effect on morbidity and mortality in a lethal infection model using a mouse-adapted SARS-CoV and also specifically inhibits deleterious aspects of the host immunological response to SARS infection in mammals.</div>
</front>
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<tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="O Keefe, Barry R" sort="O Keefe, Barry R" uniqKey="O Keefe B" first="Barry R." last="O'Keefe">Barry R. O'Keefe</name>
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<name sortKey="Mccray, Paul B Jr" sort="Mccray, Paul B Jr" uniqKey="Mccray P" first="Paul B. Jr" last="Mccray">Paul B. Jr Mccray</name>
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<name sortKey="Wohlford Lenane, Christine L" sort="Wohlford Lenane, Christine L" uniqKey="Wohlford Lenane C" first="Christine L." last="Wohlford-Lenane">Christine L. Wohlford-Lenane</name>
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   |texte=   Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae
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Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

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